Master Page 1. Add the following tag just below the form tag of master page <asp:ScriptManager ID="ScriptManager1" runat="server" EnablePartialRendering="true" /> Web.Config 1. Add safe control <SafeControl Assembly="System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35" Namespace="System.Web.UI" TypeName="*" Safe="True" /> 2. Add the http handler inside <httpHandlers> tag of web.config <add verb="*" path="*.asmx" validate="false" type="System.Web.Script.Services.ScriptHandlerFactory, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35" /> <add verb="*" path="*_AppService.axd" validate="false" type="System.Web.Script.Services.ScriptHandlerFactory, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35"